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【包邮】GDC–0077?(RG6114)
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产品编号 GC32710
Inavolisib (GDC–0077, RG6114, RO–7113755) is a potent selective inhibitor of PI3K alpha (PI3Kα) with an IC50 of 0·038 nM· GDC–0077 is >300–fold more selective for PI3K alpha over the other class I PI3K isoforms (beta, delta, and gamma) and >2000–fold more selective over PIK family members· GDC–0077 binds to the ATP binding site of PI3K and inhibits the phosphorylation of PIP2 to PIP3·
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